Delirium Clinical Pathway — CICU, PICU, and PCU

Trial of Pharmacological Therapy: Weaning Recommendations

Weaning Recommendations

  • Evaluate ability to wean/discontinue if underlying illness has resolved, and no later than 5-7 days after initiation of therapy to determine if: 
    • Underlying disease process is improving        
              AND           
    • Behaviors are well controlled  
  • Discontinue medication as soon as possible if adverse drug event is noted
  • There are no specific guidelines for weaning these medications. Discuss a plan for weaning with PICU provider, clinical pharmacy and/or Psychiatry.
  • Begin weaning as soon as possible with PRNs available while noting clinical status and pharmacological properties of the specific medication being weaned
  • Generally, duration of weaning should not exceed duration of antipsychotic therapy