N/IICU Clinical Pathway for Evaluation and Treatment of Neonates and Infants with Beckwith-Wiedemann Syndrome
- Related Pathways
- Persistent Hypoglycemia
- General Questions
- bwsclinic@chop.edu
267-425-2467
- Research Questions
- BWS@chop.edu
Care Prior to Transport or Admission to CHOP
Initial referral through CHOP Transport CallEpic Chat PHL Genetics BWS
- Making the Diagnosis
- History and Physical Examination
- Assess for BWS Features
- Genetic Testing
Cardinal Features 2 pts for each feature |
Suggestive Features 1 pt for each feature |
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Consult Genetics
If clinical score ≥ 4 or if only feature is lateralized overgrowth,
send Epic Secure Chat to PHL Genetics BWS
If clinical score ≥ 4 or if only feature is lateralized overgrowth,
send Epic Secure Chat to PHL Genetics BWS
Obtain AFP and Abdominal Ultrasound
Consult Case Management/Social Work
Identify and resolve Potential Barriers to Discharge
Identify and resolve Potential Barriers to Discharge
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Evaluation and TreatmentGenetic Testing
Discharge and Case Management
Complete safety fast and sleep study prior to discharge
Complete safety fast and sleep study prior to discharge
Evidence
- The Utility of Early Tongue Reduction Surgery for Macroglossia in Beckwith-Wiedemann Syndrome
- Clinical and Molecular Diagnosis, Screening and Management of Beckwith–Wiedemann Syndrome: an International Consensus Statement
- Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma
- Obstructive Sleep Apnea and the Role of Tongue Reduction Surgery in Children with Beckwith-Wiedemann Syndrome
- Congenital Hyperinsulinism in Children with Paternal 11p Uniparental Isodisomy and Beckwith–Wiedemann Syndrome
CHOP Programs
BWS Videos
Resources