Appendicitis — General Antibiotic Recommendations — Clinical Pathway: Inpatient
General Antibiotic Recommendations
Antibiotic Recommendations for AppendicitisRecommended Antibiotic | Second line for cephalosporin and/or severe penicillin allergy1 | Comments | |
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Please see the CHOP Formulary monograph for complete information.
Footnotes
- Severe penicillin allergy includes any of the following: anaphylaxis, angioedema, cardiac arrest, respiratory distress, severe cutaneous reaction (for example, Stevens Johnson syndrome, erythema multiforme, DRESS and TEN). Patients who experience hives with penicillin can receive cephalosporins as recommended; however, if piperacillin-tazobactam is recommended, second line antibiotics should be used. All other reactions considered non-severe and should receive the recommended antibiotic.
- An alternative drug for children who do not tolerate metronidazole is difficult to identify. Amoxicillin/clavulanate may be adequate, but an IV regimen might need to be considered.